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Models & Assays
Disease Model Efficacy
PK & Safety
Aged Beagle Model
Pathology
Aged Dogs Exhibit Both Early Amyloid-Aβ and Tau Pathologies
Drug Screening
Aβ Antibody Strategies
BACE Inhibitors
Comparative Drug Screening
Imaging
Cancer Imaging
Functional Brain Imaging
Image Processing
Interventional Imaging
Magnetic Resonance Spectroscopy
Musculoskeletal Imaging
Quantitative Magnetic Resonance
Specific Organ Imaging
Structural Brain Imaging
Whole Body Imaging
Structural Brain Imaging
MRI or CT to demonstrate structural changes in response to interventions
T1, T2. PD sequences
Diffusion Tensor Imaging to evaluate changes in myelination
Quantitative and qualitative assessment of morphological features or regions of interest by image processing
Diffusion Tensor Imaging data showing increasing fractional anisotropy in the frontal lobe, implying increasing myelination with increasing age in young beagle dogs.
Data indicating performance on the landmark allocentric learning improves with increased myelination in one year old beagle dogs.