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Models & Assays
Disease Model Efficacy
PK & Safety
Aged Beagle Model
Pathology
Aged Dogs Exhibit Both Early Amyloid-Aβ and Tau Pathologies
Drug Screening
Aβ Antibody Strategies
BACE Inhibitors
Comparative Drug Screening
Imaging
Cancer Imaging
Functional Brain Imaging
Image Processing
Interventional Imaging
Magnetic Resonance Spectroscopy
Musculoskeletal Imaging
Quantitative Magnetic Resonance
Specific Organ Imaging
Structural Brain Imaging
Whole Body Imaging
Magnetic Resonance Spectroscopy
Quantification of changes in brain chemistry associated with the development and decline of neural function in response to therapeutics
Magnetic resonance spectroscopy data showing changes in brain metabolites associated with brain development in growing beagles, including markers of neuronal health. Effects of therapeutics can be assessed in attenuating or improving brain development
Data showing change in concentration of brain metabolites in 10 year old compared to 2 year old beagle dogs