All our epilepsy models are well-validated with clinical gold standards such as lamotrigine, diazepam and carbamazepine. Routine plasma/tissue sample collection verifies the establishment of PK/PD relationships.
Examples of the models we offer include the following:
- Electrically induced seizures, e.g. MES, MEST, minEST
- Chemically evoked seizures, e.g. kainate, pentylenetetrazol
- Telemeterised EEG monitoring of brain seizure activity
- Detailed scoring of behavioural seizures according to Racine’s scale
- Concomitant assessment of therapeutic index utilising rotarod and LABORAS
- Identification of additional therapeutic utilities of novel anticonvulsants e.g. for treatment of neuropathic pain.
This list is not exhaustive, we are always developing new areas of discovery within our preclinical field of expertise. If there is something particular that is not listed here please do contact us.
