Sleep Model

Transpharmation conducts clinical and basic research studies orientated around sleep and sleep disorders with an aim of gaining a better understanding in the role of sleep in various areas instances.

Sleep Model Research

Transpharmation has a world-class reuputation in the field of Sleep / EEG research. Our expertise in this field stems from years of experience and research conducted by our management team whilst at GSK, on the central arousal effect of the hypothalamic neuropeptide orexin-A, pivotal in guiding the discovery and development of novel orexin receptor antagonists for a range of sleep disorders. At Transpharmation, we benchmark compounds against clinically relevant standards such as zolpidem and modafinil to evaluate CNS stimulant or sedative/hypnotic properties on sleep/wake cycles in rodents; supporting our clients in the development of novel molecules for a range of therapeutic indications, including sleep disorders.

Examples of sleep models we offer include:

Examples of project end points include:

  • REM, non-REM, latency to sleep onset, paradoxical sleep quantification etc.
  • Power spectral band analysis – delta, theta, gamma, beta, alpha frequencies
  • PK analysis

Tell us about your Sleep Model requirements

sleep CROThis list of sleep model services is not exhaustive, we are always developing new areas of discovery within our preclinical field of expertise. If there is something particular that is not outlined here please contact us to discuss.

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